Clara Health

Runs digital and community outreach paired with human patient navigators who stay with candidates through screening — an attempt to fix the drop-off between referral and first visit.

Program fees plus media; navigator support usually scoped separately.

Whatever the structure, convert it to cost per randomized patient before you compare proposals. Cost per referral is the number vendors prefer to quote and the number that tells you least.

• Navigator model targets the referral-to-first-visit drop-off directly
• Positioned for complex protocols that deter patients
• Publicly active in rare disease and patient advocacy

• Ask for the referral-to-visit and referral-to-randomization rates the navigator model produced on comparable studies — the added cost only pays back if those move

Worth it when: Burdensome protocols and rare indications where every candidate matters.

Not worth it when: High-volume, low-complexity studies where cheap volume wins.

• AntidoteMatches patients through a network of health advocacy and publisher partners.
• AutoCruitmentDirect-to-patient digital recruitment with a proprietary pre-screener.
• Science 37Decentralized trial operating system with telemedicine investigators and nurses.

• AutoCruitment vs Clara Health — Referral volume versus navigated conversion.

Ask for the referral-to-randomization ratio on three studies resembling yours, in the same indication and the same countries. If a vendor will not give it, that is the answer. If your enrollment forecast itself is the shaky part, our sister publication Rock Enroll covers forecasting and rescue in depth.