ThreeWire

Combines outreach with hands-on site support: referral follow-up, chart review support, and helping sites convert referrals rather than only generating them. Notable presence in medical device and cardiovascular studies.

Service-based, usually scoped per site and per activity.

Whatever the structure, convert it to cost per randomized patient before you compare proposals. Cost per referral is the number vendors prefer to quote and the number that tells you least.

• Sells site-side execution, not only lead generation
• Publicly references device and procedure-based trial work
• Long operating history

• Ask what share of a typical program is digital versus field-based, and how that matches your population
• Ask how the site-by-site model scales across a large site footprint and what it costs per added site

Worth it when: Device and procedural studies where site conversion is the bottleneck.

Not worth it when: Sponsors who mainly need cheap top-of-funnel volume.

• MMGCommunications-led agency covering recruitment, retention, and engagement.
• Continuum ClinicalRecruitment and retention with strong site-engagement programs.
• Blue Chip Patient RecruitmentFull-service recruitment and retention, part of a larger marketing group.

• ThreeWire vs Blue Chip Patient Recruitment — Site execution versus full-service program.

Ask for the referral-to-randomization ratio on three studies resembling yours, in the same indication and the same countries. If a vendor will not give it, that is the answer. If your enrollment forecast itself is the shaky part, our sister publication Rock Enroll covers forecasting and rescue in depth.